A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Narayana Swamy, V. B.
- Isolation and Evaluation of Basella alba Linn. Leaf Mucilage as Release Retardant in Tablet Formulation
Authors
1 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmacognosy, Karavali College of Pharmacy, Vamanjoor, Mangalore, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 2 (2016), Pagination: 81-94Abstract
In recent years, plant derived polymers have evoked tremendous interest due to their diverse pharmaceutical applications such as diluent, binder, disintegrate in tablets, thickeners in oral liquids, protective colloids in suspensions, gelling agents in gels and bases in suppository, they are also used in cosmetics, textiles, paints and paper-making. Basella alba is a wildly cultivated, cool season vegetable with climbing growth habit. Malabar spinach is high in vitamin A, vitamin C, iron and calcium. In the present work, an attempt was made to develop matrix tablets of diclofenac using natural release retardant isolated from Basella alba leaves and its efficiency was compared with most widely used natural release retardant like guar gum.
Diclofenac matrix tablets were formulated by using BAM in different concentrations (2.5%, 5%, 7.5%, 10% and 12.5%) by wet granulation method and its efficiency was compared with guar gum. The granules prepared were free flowing with good compressibility. Formulated tablets were evaluated for hardness, thickness, friability, weight variation, drug content, in vitro disintegration time, swelling studies and in vitro dissolution studies.
The hardness of the tablets was found to be 6-7 kg/cm2 and percentage friability of tablets was found to be less than 0.1% in all the cases and swelling index studies shown that as the conc. of polymer increased there was a proportional increase in the swelling index of tablet. Among the formulation studied, formulation F5 showed release of drug more than 12hrs and formulation F5 showed optimum release characteristics. The release was found to follow the anomalous non-Fickian diffusion. It revealed that as the conc. of polymer in tablet increased the release of the drug from the tablet decreased. It shown that BAM exhibited excellent retarding effect on drug release from the matrix tablets even at very low concentrations. Stability studies were carried out at 400C±20C/75%±5% RH for formulation F5 for 30 days. The results of stability studies indicated no significant changes with respect to physicochemical properties, in vitro disintegration time, swelling index and in vitro drug release.
Keywords
Matrix Tablets, Diclofenac, Basella alba Mucilage, Release Retardant, Wet Granulation, Guar Gum.- Formulation and Evaluation of Fast Dissolving Tablets of Trimetazidine Dihydrochloride Using Natural and Synthetic Superdisintegrants
Authors
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
3 Department of Pharmacognosy, Karavali College of Pharmacy, Vamanjoor, Mangalore, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 2 (2016), Pagination: 95-104Abstract
Plant products serve as an alternative to synthetic products because of local accessibility, eco friendly nature and lower price compared to imported synthetic products. Natural gums and mucilage have been widely explored as pharmaceutical excipients. Tablet disintegration has received considerable attention as an essential step in obtaining fast drug release. The present work was carried out to study the disintegration properties of Plantago Ovata mucilage powder by formulating orally disintegrating tablets of Trimetazidine hydrochloride by direct compression method. Disintegrant property of above disintegrants was evaluated by comparing their formulations with the formulations of various superdisintegrants extracted Mucilage was subjected to toxicity studies for its safety and preformulation studies for its suitability as a disintegrating agent. The extracted mucilage is devoid of toxicity. No chemical interaction between drug and excipients was confirmed by FTIR and DSC studies. Mouth dissolving tablets of Trimetazidine hydrochloride were prepared and compared with different concentrations viz; 0.5, 1, 1.5, 2.0 and 2.5% (w/w) of Plantago Ovata mucilage powder, cross carmellose sodium and sodium starch glycolate. Thirty six formulations were prepared by using different diluents and evaluated for physical parameters such as thickness, hardness, friability, weight variation, drug content, disintegration time and drug dissolution. The formulated tablets had good appearance and better drug release properties. The study revealed that Plantago Ovata mucilage powder was effective as disintegrant in low concentrations (1%). The mucilage was found to be a superior disintegrating agent than sodium starch glycolate and cross carmellose sodium. Studies indicate that the extracted mucilage may be a good source of pharmaceutical adjuvant, specifically a disintegrating agent.Keywords
Fast Dissolving Tablet, Trmetazidine Dihydrochloride, Superdisintegrant, Direct Compression, Plantago Ovate, Sodium Starch Glycolate, Cross Carmellose Sodium, Cross Povidone.- Formulation and Evaluation of Immediate Release Pravastatin Sodium Tablets
Authors
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN